Low Prevalence of ETV6::RUNX1 Fusion Gene in a Hispanic Population

Low Prevalence of ETV6::RUNX1 Fusion Gene in a Hispanic Population

Blog Article

ETV6::RUNX1 is a genetic rearrangement of good prognosis in children with acute lymphoblastic leukemia (ALL).In Mexico, its prevalence is low in comparison with Caucasian populations.We developed a Goku novel TaqMan one-step RT-qPCR approach to assess the prevalence of four genetic rearrangements in a cohort of Hispanic children with ALL from Mexico City.

The prevalence of common fusion gene transcripts was as follows: TCF3::PBX1 7.7%; BCR::ABL1p190 3.3%; and KMT2A::AFF1 2.

8%, and ETV6::RUNX1was observed with low prevalence (10.5%) in comparison to that reported for developed countries.This is consistent with previous findings on Mexican children with ALL and similar to those reported on children from Hispanic populations.

The confirmation of a low prevalence of ETV6::RUNX1 in Acrylic Fridge Magnet children of a Hispanic origin represents an advancement in the description of genetic factors of ALL in these populations.